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Background The vascular effects exerted by GLP-1 are mediated by several synergistic mechanisms such as involvement of nitric oxide and natriuresis. Recently, it was demonstrated that atrial natriuretic peptide (ANP) is essential for the glucagon-like peptide-1 (GLP-1)-stimulated vascular smooth muscle relaxation that mediates anti-hypertensive action in rodents. Therefore a GLP-1–ANP axis has been...
Aims/hypothesis The aim of this study was to determine whether exenatide improves haemodynamic function in patients with type 2 diabetes with congestive heart failure (CHF). Methods The main eligibility criteria for inclusion were: male/female (18–80 years) with type 2 diabetes and CHF (ejection fraction ≤35%, and New York Heart Association functional class III or IV). Out of 237 patients screened,...
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