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NK cells play important roles in innate immunity against tumors and infections of the host. Studies show that CD107a (LAMP-1) may be a marker for degranulation of NK and activated CD8 + T cells. In our study, the relationship between the expression of CD107a, cytokine secretion and cytotoxic activity in CD56 + NK, CD8 + T cells and lymphocytes has been determined after various...
Splenocytes cultured in the presence of 30–60 units/ml IL-2 for 5 days develop natural killer activity toward syngeneic and allogeneic tumor cell targets. The IL-2 activated splenocytes, themselves, are partially resistant, whereas concanavalin A-activated T blast cells are completely resistant to killing. Surprisingly, major histocompatibility complex (MHC)-I-negative target cells are also resistant...
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