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Results of recent studies using BAPTA/AM have raised a serious question on whether Ca 2+ signal is truly involved in regulating the progression of apoptosis. To resolve this question, we examined the differential effects of three different Ca 2+ signaling blockers (BAPTA/AM, membrane-impermeant BAPTA, and heparin) on UV-induced apoptosis in HeLa cells. We found that although the membrane-permeable...
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