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Three alkaloids, aknadinine, 1-nitroaknadinine and sinococuline, isolated from Stephania sutchuenensis were studied for their effects on a fibroblast cell line, eight tumour cell lines and a rat alveolar macrophage culture. Sinococuline is an effective tumour cell growth inhibitor whereas the toxicity of aknadinine and 1-nitroaknadinine towards all tested cells is low. A dose-dependent decrease in...
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