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Previous findings from our laboratory demonstrated that when used at low concentration (0.1 μg ml -1 ), CsA as well as its analog PSC 833 were able to revert the MDR phenotype, while at high concentration (1 μg ml -1 ) were able to induce apoptosis. CsA induced apoptosis in leukemia cell lines sensitive (LBR-) and resistant to vincristine (LBR-V160), and doxorubicin (LBR-D160),...
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