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Vascular complications are what eventually threaten the lives of diabetic patients. Here we show direct in vivo evidence that the interaction between advanced glycation end products (AGE), the formation of which is accelerated during prolonged hyperglycemic exposure, and a cell surface receptor for AGE (RAGE) is the major cause of such complications. We created transgenic mice that overexpress human...
The permeability of glomerular basement membrane (GBM) was assessed in vitro by the filtration of solutions of proteins across films formed from isolated pig GBM. Incubation of the films with fructose or glucose increased their permeability to water and serum albumin. The effect of fructose was similar to that previously noted for films crosslinked with glutaraldehyde. The metal chelator DTPA abolished...
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