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Prostaglandins (PG) are produced by the enzymatic activity of cyclooxygenase (COX). PGs and COX have been implicated in the pathophysiology of excitotoxicity and neurodegeneration in the central nervous system (CNS). The PGE 2 receptor EP3 is the most abundantly expressed PGE 2 receptor subtype in the brain. So far, in the innate rat brain EP3 receptors have been found exclusively...
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