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Steatohepatitis (SH) is associated with mitochondrial dysfunction and excessive production of superoxide, which can then be converted into H 2 O 2 by SOD2. Since mitochondrial GSH (mGSH) plays a critical role in H 2 O 2 reduction, we explored the interplay between superoxide, H 2 O 2 , and mGSH in nutritional and genetic models of SH, which exhibit mGSH...
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