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Oxidative stress plays an important role in mediating ventricular remodeling and dysfunction in heart failure (HF), but its mechanism of action has not been fully elucidated. In this study we determined whether a combination of antioxidant vitamins reduced myocyte apoptosis, β-adrenergic receptor desensitization, and sarcoplasmic reticular (SR) Ca 2+ ATPase downregulation in HF after myocardial...
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