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The activation of N-methyl-D-aspartate receptors is implicated in the spinal and trigeminal processing of nociceptive information conveyed by convergent (wide dynamic range) neurons and particularly in C-fiber-evoked responses elicited by repetitive and high-intensity electrical stimulation of the neuronal receptive field. In this study, the effects of intrathecal NMDA application on the electrically...
ALVAREZ-VEGA, M., A. BAAMONDE, M. GUTIERREZ, A. HIDALGO AND L. MENENDEZ. Intrathecal N-methyl-d-aspartate (NMDA) induces paradoxical analgesia in the tail-flick test in rats. PHARMACOL BIOCHEM BEHAV 65(4) 621-625, 2000.-The intrathecal (IT) administration of NMDA in rodents has usually been reported to produce hyperalgesic reactions, although some articles describe that spinal NMDA can lead to analgesia...
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