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Emerging evidence favors the notion that macrophage autophagy plays a prominent role in the pathogenesis of vulnerable plaque, suggesting the therapeutic potential of targeting autophagy in atherosclerosis. Here ApoE−/− mice were crossed with Mst1 knockout or Mst1 Tg mice to generate ApoE−/−:Mst1−/− and ApoE−/−:Mst1Tg mice. All animals were fed high-fat-diet for 4months to induce arterial atherosclerosis...
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