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Endothelin-1 (ET-1) is a major regulator of vascular function, acting via both endothelin receptor type A (ET A R) and type B (ET B R). Although the role of ET A R in vascular smooth muscle (VSM) contraction has been studied, little is known about ET B R. ET B R is a G-protein coupled receptor with a molecular mass of ∼50kDa and 442 amino acids arranged in seven...
A rise in blood pressure is the main side effect of erythropoietin (EPO) treatment in patients with renal anemia. The mechanisms, however, by which EPO may cause hypertension are still unclear. We therefore investigated the effects of EPO on endothelin (ET) synthesis and cytosolic free calcium concentration ([Ca 2+ ] i ) in vascular endothelial cells. Porcine endothelial cells...
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