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We investigated the effect of type 1 human immunodeficiency virus (HIV-1) regulatory protein Tat on N-methyl-d-aspartate (NMDA) receptors expressed in Xenopus oocytes by voltage-clamp recording and its role in NMDA-mediated neurotoxicity using cultured rat hippocampal neurons. Tat (0.01–1μM) potentiated NMDA-induced currents of recombinant NMDA receptors. However, in the presence of Zn 2+ ...
JAMES, F., J. FLOOD AND E. MORLEY. Learning and memory in the SAMP8 mouse. NEUROSCI BIOBEHAV REV 21 (0) 000-000.-The SAMP8 (P8) mouse strain develops deficits in learning and memory relatively early in its lifespan. This review provides an overview of the age-related changes that occur in P8 mice. Behavioral studies with P8 mice show impaired acquisition and retention as early as 4 months of age....
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