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The cellular location of 5-HT 1A and 5-HT 1B binding sites in the hippocampus was investigated using a stereotaxic unilateral lesion of the CA1 field by ibotenic acid, followed by autoradiography on brain sections with the specific ligands [ 3 H]8-OH-DPAT and S-CM-G[ 125 I]TNH 2 , respectively. As compared to the contralateral side of the...
This study examines the effect of castration and androgen replacement on [ 125 I]MK801 binding in the hippocampus. In castrated male rats, [ 125 I]MK801 binding was significantly increased in both the stratum oriens and radiatum and the pyramidal cell layer of CA1. In contrast, no increase in [ 125 I]MK801 binding was observed in the stratum...
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