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In this work chitosan microspheres have been prepared by ion precipitation using sodium sulfate as precipitant, and crosslinked with natural crosslinker genipin. Then the microspheres were hydrophobically modified by covalent and ion interaction grafting of stearic acid and sodium stearate respectively. Results indicated that the there were still some amount of –NH 2 groups on the genipin-crosslinked...
Genipin, a natural and non-toxic cross-linking reagent, was evaluated for its effects on the drug/protein release and swelling of chitosan microspheres. Chitosan microspheres, using albumin as a model protein, were prepared and cross-linked with 0.5mM genipin for 4 to 16h or for 4h using 0.5 to 2.0mM genipin. The degree of cross-linking, swelling and the release of albumin from the microspheres was...
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