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The toxic behaviour of the two shorter sequences of the native Aβ amyloid peptide required for cytotoxicity i.e., Aβ(31–35) and Aβ(25–35) peptides, was studied. We have shown that Aβ(31–35) peptide induces neurotoxicity in undifferentiated PC 12 cell via an apoptotic cell death pathway, including caspase activation and DNA fragmentation. Aβ(25–35) peptide, like the shorter amyloid peptide has the...
In order to clarify the basis of neuronal toxicity exerted by the shortest active peptides of amyloid beta-protein (Aβ), the toxic effects of Aβ(31–35) and Aβ(25–35) peptides on isolated rat brain mitochondria were investigated. The results show that exposure of isolated rat brain mitochondria to Aβ(31–35) and Aβ(25–35) peptides determines: (i) release of cytochrome c; (ii) mitochondrial swelling...
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