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Dysregulation of intracellular Ca2+ homeostasis has been proposed as a common proximal cause of neural dysfunction during aging and Alzheimer’s disease (AD). In this context, aberrant Ca2+ signaling has been viewed as a neuronal phenomenon mostly related to the dysfunction of intracellular Ca2+ stores. However, recent data suggest that, in AD, Ca2+ dyshomeostasis is not restricted to neurons but represents...
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