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Evidence from human postmortem material, transgenic mice, and cellular/animal models of PD link alpha‐synuclein accumulation to alterations in the autophagy lysosomal pathway. Conversely, alpha‐synuclein mutations related to PD pathogenesis, as well as post‐translational modifications of the wild‐type protein, result in the generation of aberrant species that may impair further the function of the...
BackgroundTo establish whether Parkinson's disease (PD) brains previously described to have decreased glucocerebrosidase activity exhibit accumulation of the lysosomal enzyme's substrate, glucosylceramide, or other changes in lipid composition.
MethodsLipidomic analyses and cholesterol measurements were performed on the putamen (n = 5‐7) and cerebellum (n = 7‐14) of controls, Parkinson's disease...
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