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This study evaluated a prolonged effect of palm oil addition to lard‐supplemented diet (PLD) on the oxidative status, lysosomal enzyme activities, markers of hepatotoxicity and basic lipid profile in female rats. Female Sprague‐Dawley rats received PLD (10% of total fat: 7.5% from palm oil and 2.5% from lard), and the control group received lard‐supplemented diet (2.5% fat) from 28 days of age for...