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To determine which prostaglandin E 2 (PGE 2 ) receptor subtypes are involved in the brain-derived PGE 2 -induced changes in nociception, we injected synthetic EP 1 , EP 2 and EP 3 receptor agonists (0.01 fmol to 10 nmol) into the lateral cerebroventricle (LCV) of urethane-anesthetized rats and observed the changes in the responses of the wide dynamic...
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