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This study utilized a grease-gap preparation to investigate the effects of polyamines on responses of CA1 hippocampal pyramidal cells to N-methyl-d-aspartate (NMDA) and on the block of the NMDA channel by Mg 2+ . In the absence of added Mg 2+ , 1,10-diaminodecane (0.1-1 mM) non-competitively antagonized NMDA-evoked depolarizations. Its antagonism slowly progressed to a stable...
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