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Cutaneous melanoma (CM) is an extremely aggressive cancer presenting low survival and high mortality. The vast majority of patients affected by this disease does not respond or show resistance to the chemotherapeutic drugs, which makes the treatment ineffective. In this sense, the necessity for the development of new agents to assist in CM therapy is extremely important. One of the sources of great...
The microenvironment of a tumour differs significantly from that of a normal tissue due to abnormal vasculature and altered cellular metabolism in tumours. Microenvironmental conditions in tumours, which include hypoxia, acidity, nutrient deprivation and high interstitial fluid pressure, have been associated with metastatic tumour progression both experimentally and clinically. The mechanisms by which...
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