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Transient receptor potential (TRP) channels affect several physiological and pathological processes. In particular, TRP channels have been recently involved in the triggering of enhanced proliferation, aberrant differentiation, and resistance to apoptotic cell death leading to the uncontrolled tumor invasion. About thirty TRPs have been identified to date, and are classified in seven different families:...
Neoplasia pathogenesis and resistance to therapy are largely determined by acquired resistance to apoptosis. Among apoptosis- regulating molecules, a role is emerging for BAG3, a member of the BAG co-chaperone protein family. Through its bag, WW and prolix-rich domains, BAG3 protein can interact with a variety of molecular partners, including Hsc70/Hsp70, phospholipase C- gamma and others. It has...
The extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein (MAP) kinase module is a conserved signaling pathway that plays a major role in the control of cell proliferation, survival and differentiation. This pathway is typically turned on by engagement of growth factor receptors, which leads to the activation of the small GTPase Ras and to sequential phosphorylation and activation...
Increased generation of reactive oxygen species (ROS) is observed in many types of cancer cells. Besides the well-recognized effect of ROS in causing mutations and promoting cancer cell growth, recent evidence further suggests the involvement of oxidative stress in anticancer drug resistance. Consistent with the tumor-promoting effect of ROS, many in vitro studies have reported tumor-suppressing properties...
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