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Background
βIII‐tubulin (TUBB3) is an isotype of microtubules, which are involved in crucial cellular roles including maintenance of cell shape, intracellular transport, and mitosis. Overexpression of TUBB3 was found to be associated with poor prognosis and resistance to tubulin‐binding drugs and in several solid tumors including head and neck squamous cell carcinomas (HNSCC). Considering the potential...
BackgroundWe postulated that disruptions of the canonical transforming growth factor‐beta (TGF‐β)/Smad signaling pathway might contribute to the development of head and neck squamous cell carcinoma (HNSCC).
MethodsA cohort of 798 HNSCC tumor samples from 346 patients were analyzed by immunohistochemistry (IHC) to define the pattern of expression of (phospho)Smad2, (phospho)Smad3, and Smad4.
ResultsWe...
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