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Cellular communication relies on signaling circuits whose statuses are mainly modulated by soluble biomolecules such as carbohydrates, lipids, proteins, and metabolites as well as extracellular vesicles (EVs). Therefore, the active secretion of such biomolecules is critical for both cell homeostasis and proper pathophysiological responses in a timely fashion. In this context, proteins are among the...
Over the past decades, substantial advances have been made in both the early diagnosis and accurate prognosis of many cancers because of the impressive development of novel proteomic strategies. However, it remains difficult to standardize proteomic approaches. In addition, the heterogeneity of proteins in distinct tissues results in incomplete population of the whole proteome, which inevitably limits...
The CA 19‐9 antigen is currently the best individual marker for the detection of pancreatic cancer. In order to optimize the CA 19‐9 assay and to develop approaches to further improve cancer detection, it is important to understand the specificity differences between CA 19‐9 antibodies and the consequential affect on biomarker performance. Antibody arrays enabled multiplexed comparisons between five...
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