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In this paper we summarise our current work on using Process Calculi for the modelling and analysis of biological pathways in context of better understanding respiratory disease. We present and highlight key features of some of the different Process Calculi that have been used for the modelling of biological pathways. Then we make a state-of-art on asthma, severe asthma and the possible cause of corticosteroids...
Chest physiotherapy is widely used for newborn babies suffering from bronchiolitis, despite the lack of studies regarding the technique. Qualitative protocols for Chest Physiotherapy technique have been established but no quantitative definition has been made to prove the efficiency or to characterize the gestures. Thus, with the growth in demand for training from the physiotherapy's community, we...
This paper presents an evidential segmentation scheme of respiratory signals for the detection of the wheezing sounds. The segmentation is based on the modeling of the data by evidence theory which is well suited to represent such uncertain and imprecise data. In this paper, we particularly focus on the modelization of the data imprecision using the fuzzy theory. The modelization result is then used...
Snore is a problem, which can be seen in many people and has consequences from disrupting the individual's harmony with environment up to divorce as a familial problem. Snoring patients are analysed in two groups as simple snorers and snorers with obstructive sleep apnea syndrome (OSAS). Obstructive sleep apnea syndrome (OSAS) is a disease causing serious problems in patients by cessation of upper...
A multiscale mathematical model was developed to distinguish responses of external and cellular respiration to exercise of moderate intensity. The simulation shows that the characteristic MRTs of external and cellular respiration are similar even when a transit delay exists between the tissue cells and the lungs. The results of our model show that the O2 transport processes from lungs to muscle are...
This contribution presents an application of time-domain transmittance approximation for non-integer order parametric models. The study case consists of averaged values for input respiratory impedance from subjects diagnosed with chronic obstructive pulmonary disease (COPD). A classical PI controller is designed via computer aided design tools based on frequency response and given specifications as...
Mechanical ventilation is often used to treat patients with acute respiratory distress syndrome (ARDS). However, the optimal setting is still controversial, and physicians often rely on experience and intuition. The purpose of this research is to develop a model of the essential lung mechanics to help determining the optimal ventilator setting in clinical situations. The model is a compilation of...
Expiratory flow limitation (EFL) is frequent in mechanically ventilated patients with obstructive pulmonary disease and its prompt detection is important to optimize respiratory assistance. The present study aims to compare by simulation two methods for the detection of flow limitation in intensive care unit: the negative expiratory pressure (NEP) method and the external resistance (/spl Delta/R)...
Understanding the respiratory control system and the ventilatory pattern under hypercapnic stimulus is important to interpret the acute exacerbation of COPD and the condition of patients connected to mechanical ventilation. The purpose of this study is the analysis of respiratory and muscle parameters in order to obtain the most sensitive and characteristic of different levels of hypercapnic stimulus...
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