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A computational mutagenesis is detailed whereby each single residue substitution in a protein chain of primary sequence length N is represented as a sparse N-dimensional feature vector, whose M ≪ N nonzero components locally quantify environmental perturbations occurring at the mutated position and its neighbors in the protein structure. The methodology makes use of both the Delaunay tessellation...
Currently, relation extraction (RE) and event extraction (EE) are the two main streams of biological information extraction. In 2009, the majority of these RE and EE research efforts were centered around the BioCreative II.5 Protein-Protein Interaction (PPI) challenge and the “BioNLP event extraction shared task.” Although these challenges took somewhat different approaches, they share the same ultimate...
Identifying protein-protein interaction sites have important connotations ranging from rational drug design to analysis metabolic and signal transduction networks. In this paper, we presented an adapted Bayesian classifier based on tree augmented naiumlve Bayesian classifier to predict interface residues of protein-protein interaction sites. This classifier used fixed structure which could denote...
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