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NRG1 is one of the most researched genes associated with schizophrenia. Although three meta-analyses in this area have been published, the results have been inconclusive and even conflicting. Family based studies can be problematical due to the difficulty of synthesizing them with case-control studies. Heterogeneity is another persistently difficult problem which tends to be side-stepped in genetic...
Meta-analytic methods were used to test the D 2 dopamine density hypothesis in schizophrenia. Post-mortem as well as in-vivo (i.e., PET and SPECT) neuroimaging studies that met criteria for inclusion into the meta-analysis were gathered from 1980 to 1996. The mean effect size across studies corresponds to an effect size of 1.47 (d). Although large, the effect size obtained does not meet heuristic...
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