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We assessed the effects of systemically injected baclofen, a GABA B agonist, on single and paired-pulse responses in the dentate gyrus of urethane-anesthetized rats, in vivo. Baclofen (10 mg/kg) significantly increased the duration of single excitatory responses. This increase was blocked by the GABA B receptor antagonist, CGP 35348, indicating that baclofen was acting through GABA...
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