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We studied the neurotoxic glutamate release induced by high-K + depolarization in rat hippocampal slice cultures. Depolarization with 90 mM K + for 30 min caused a significant, three-fold increase in glutamate release. This release was not inhibited by removing extracellular Ca 2+ , but was significantly inhibited by replacement of extracellular Cl - with SO...
The neurotoxicity induced by depolarization with high-K + was investigated in rat hippocampal organotypic slice cultures. The exposure of cultures to 90 mM K + solution for 30 min caused a severe neuronal injury in CA1 region while less damage was observed in CA3 and dentate gyrus over the following day. This neurotoxicity was prevented in a concentration dependent manner by NMDA...
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