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The effects of somatostatin on the impairment of working memory induced in rats by blockade of hippocampal muscarinic M 1 or NMDA receptors were examined, using a three-panel runway task. Both the muscarinic M 1 receptor antagonist pirenzepine (1.0 μg/side) and the competitive NMDA receptor antagonist CPP ((±)-3(2-carboxypiperazin-4-yl)-propyl-1-phosphonoic acid) (32 ng/side) significantly...
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