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Intrahippocampal administration of (R,S)-1-aminoindan-1,5-dicarboxylic acid (AIDA), a potent and selective antagonist of the group I metabotropic glutamate receptor (mGluR), at doses of 0.32-3.2 μg/side dose-dependently increased the number of errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points) in the working memory task with a three-panel runway setup...
d-Cycloserine, a partial agonist at the glycine binding site on the NMDA receptor/channel complex, did not affect the number of errors (attempts to pass through two incorrect panels of the three-panel gates at four choice points) in the working memory task with a three-panel runway setup, when injected bilaterally at 1 or 10 μg/side into the dorsal hippocampus. Intrahippocampal administration of the...
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