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Alzheimer’s disease is a neurodegenerative disease that affects 44 million people worldwide, costing the world $605 billion to care for those affected not taking into account the physical and psychological costs for those who care for Alzheimer’s patients. Dipentylammonium is a simple amine, which is structurally similar to a number of other identified sigma-1 receptor ligands with high affinities...
Adenosine receptors modulate neuronal and synaptic function in a range of ways that may make them relevant to the occurrence, development and treatment of brain ischemic damage and degenerative disorders. A1 adenosine receptors tend to suppress neural activity by a predominantly presynaptic action, while A2A adenosine receptors are more likely to promote transmitter release and postsynaptic depolarization...
Glutamate is the most abundant excitatory brain neurotransmitter that has important functional significance with respect to neurodegenerative conditions. Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer’s disease (AD) has been gradually becoming elucidated recently. Excessive release of glutamate induces an increase in intracellular Ca2+ levels, thus triggers a cascade of cellular...
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