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Aim
To test the hypothesis that the addition of periodic courses of short‐term intensive insulin therapy (IIT) could enhance the effect of metformin (MET) maintenance therapy on preservation of beta‐cell function following induction IIT.
Methods
In this multicentre, randomized controlled trial, 108 adults with type 2 diabetes (median 1.3 years’ duration; HbA1c 6.6% ± 0.6%) were randomized to 3...
Aims
To test the hypothesis that “induction” intensive insulin therapy (IIT) needs to be followed by “maintenance therapy” to preserve β‐cell function, and to evaluate the impact on β‐cell function over 2 years of two approaches to maintenance therapy: intermittent short‐term IIT every 3 months vs daily metformin.
Materials and methods
In this trial, 24 adults with a mean type 2 diabetes mellitus...
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