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Purpose We aimed to evaluate the associations between androgenetic alopecia at a young age and subsequent development of aggressive prostate cancer (PC). Methods Using a case–control design with self-administered questionnaire, we evaluated the association between aggressive PC and very early-onset balding at age 20, and early-onset balding at age 40 years in 1,941 men. Cases were men with high-grade...
Prostate cancer is the most frequently diagnosed malignancy and second leading cause of cancer death in men in Western countries. Little is understood about its causes, but steroid hormones, particularly androgens, are suspected to play a major role. Human populations at high risk for prostate cancer may have slightly higher androgen production, circulating androgens, 5α-reductase activity, or androgen...
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