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Banks, W. A., J. B. Jaspan, W. Huang and A. J. Kastin.Transport of insulin across the blood-brain barrier: Saturability at euglycemic doses of insulin.Peptides 18(9) 1423-1429, 1997.-Blood-borne insulin is known to cross the blood-brain barrier (BBB) where it can act as a satiety peptide. We examined in mice the pharmacokinetics and characteristics of such passage by multiple-time regression analysis...
Banks, W. A., J. B. Jaspan and A. J. Kastin.Selective, physiological transport of insulin across the blood-brain barrier: Novel demonstration by species-specific radioimmunoassays.Peptides 18(8) 1257-1262; 1997.-Insulin in blood is thought to cross the blood-brain barrier (BBB) to act within the brain to help control appetite. We examined the ability of blood-borne insulin to cross the BBB. Human...
Insulin derived from the peripheral circulation has been shown to exert various effects on the brain due to its ability to cross the blood-brain barrier (BBB). The relation between diabetes mellitus and insulin has been extensively studied for peripheral tissues but not for central nervous system tissues. We examined the effects that streptozotocin- or alloxan-induced diabetes have on the transport...
In skeletal muscle insulin induces the translocation of both the GLUT4 glucose transporter and the α2 subunit of the Na,K-ATPase from an intracellular membrane (IM) compartment to the plasma membrane (PM). Fractionation studies of rat skeletal muscle using a discontinuous sucrose gradient have indicated that the insulin-induced loss of both proteins occurs from a fraction containing intracellular...
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