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Familial British and familial Danish dementia (FDD) are progressive neurodegenerative disorders characterized by cerebral deposition of the amyloidogenic peptides ABri and ADan, respectively. These amyloid peptides start with an N-terminal glutamate residue, which can be posttranslationally converted into a pyroglutamate (pGlu) modified form, a mechanism which has been extensively described to be...
J. Neurochem. (2012) 121, 774–784.
AbstractPyroglutamate (pGlu)‐modified amyloid peptides have been identified in sporadic and familial forms of Alzheimer’s disease (AD) and the inherited disorders familial British and Danish Dementia (FBD and FDD). In this study, we characterized the aggregation of amyloid‐β protein Aβ37, Aβ38, Aβ40, Aβ42 and ADan species in vitro, which were modified by N‐terminal...
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