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Obwohl die Glottis im Grunde zur Chemoprävention prädisponiert ist, werden derzeit nahezu alle laryngealen Dysplasien von Stadium I bis hin zum Carcinoma in situ exzidiert. In der Übersicht werden einige ausgewählte molekularbiologische Aspekte mit besonderer Beziehung zur Dysplasie des Larynx und therapeutischer Relevanz vorgestellt und aktuell favorisierte Biomarker zur Chemoprävention laryngealer...
Background Dysplastic squamous epithelium is a precancerous lesion for squamous cell carcinoma. It is often present in the esophagus and head and neck region, and can be visualized as a Lugol-voiding lesion (LVL) by iodine chromoendoscopy. However, effective treatment for such dysplastic epithelia has not yet been developed. Methods Between March 2008 and July 2011, 40 consecutive patients with...
Neoangiogenesis is required for the growth of invasive lung carcinoma, however, the role of angiogenesis in the progression of premalignant changes to carcinoma of the lung is less clear. We have evaluated vascular endothelial growth factor (VEGF) expression and microvessel densities (MVDs) in 62 bronchoscopic biopsies from normal, reactive (basal cell hyperplasia (BCH)) and dysplastic bronchial epithelium...
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