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The present study explored the role of different sub-types of voltage-activated Ca 2+ channels (VACCs) in mediating veratridine-evoked [ 3 H]dopamine (DA) release from rat striatal slices. The release of [ 3 H]DA evoked by veratridine (25 μM) decreased by 50.6+/-2.9% (n=8) in the absence of calcium ions and was completely abolished by 1 μM tetrodotoxin. The L-type Ca ...
Opiate tolerance has been associated with changes in neuronal intracellular calcium levels. In vivo studies have indicated the involvement of dihydropyridine (DHP)-sensitive (‘L-type’) voltage-gated calcium channels in the morphine-tolerant state. In this study, we assessed how the morphine-tolerant state would affect the antinociception produced by intrathecal administration of two agents (Bay K...
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