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Experimental models have implicated glutamate in the irreversible damage to retinal cells following retinal detachment. In this retrospective study we investigated a possible role for glutamate and other amino acid neurotransmitters during clinical rhegmatogenous retinal detachment (RRD). Undiluted vitreous samples were obtained from 176 patients undergoing pars plana vitrectomy. The study group consisted...
Purpose: To investigate the response of the retina to an ischemic insult, we measured the levels of glutamate in the vitreous of rabbit eyes.Methods: Ocular ischemia was induced in the vitreous of rabbit eyes by simultaneous ligature of the optic nerve, ciliary arteries, and extraocular muscles for 45 minutes. Contralateral eyes were subjected to a conjunctival peritomy to serve as sham-operated controls...
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