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The development of technologies for live optical imaging of exocytosis has improved the understanding of secretion. We investigated the insulin exocytotic mechanism with two-photon imaging methods in intact pancreatic islets. These studies revealed that high glucose levels induce two phases of insulin secretion and that this release is dependent upon cytosolic calcium (Ca2+). This technology has also...
Aims/hypothesis Islet antigen 2 (IA-2) and IA-2β are dense core vesicle (DCV) transmembrane proteins and major autoantigens in type 1 diabetes. The present experiments were initiated to test the hypothesis that the knockout of the genes encoding these proteins impairs the secretion of insulin by reducing the number of DCV. Methods Insulin secretion, content and DCV number were evaluated in islets...
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