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Near-infrared (NIR) spectroscopy is a versatile technique for non-destructive analysis of pharmaceutical tablet coating thickness; however, it needs a calibration model and thus the prior knowledge about the coating thickness of each tablet is required. In this work, we demonstrate that Terahertz Pulsed Imaging (TPI) can provide, in a nondestructive fashion, such coating thickness information for...
Existing studies terahertz pulsed imaging and spectroscopy to be safe techniques for biomedical applications. Coherent detection in terahertz pulsed imaging enable it to probe a wide range of information of unknown objects in both time and frequency domains. These distinctive features have recently spurred numerous research into human and animal tissues. We previously reported the dielectric properties...
We present an analysis of terahertz pulsed imaging (TPI) measurements made on pharmaceutical tablets compacted at a range of compression forces. In particular, we investigate the uniformity and local variations in the refractive index on the surface of tablets of different shapes. Through terahertz imaging it has been possible to observe small-scale deviations on tablet surfaces that may have relevance...
Terahertz pulsed imaging (TPI) is a powerful tool for non-destructive quantification of pharmaceutical tablet coatings. In this paper, we present a Neural Network (NN) based method for extracting the coating thickness from the FFT-amplitude of the measured terahertz waveform. We demonstrate that the NN-based frequency domain method outperforms the standard “peak-finding” time-domain method, in terms...
The characteristics of non-ionising radiation and sensitivity to water increase the potential of Terahertz Pulsed Imaging (TPI) to become a new biomedical imaging technique. Furthermore, the design of a portable probe in the TPI system by TeraView has improved the flexibility of the TPI system. In this paper we present recent work using the THz probe to measure the skin in different positions on the...
Terahertz radiation can penetrate through most non-conducting materials. Imaging with terahertz waves for these materials could provide an appropriate contrast compared with infrared, visible light and X-ray. Edge diffraction in terahertz pulsed imaging (TPI) enables the image contrast to be further enhanced, which exhibits considerable application potential to recognize shape features in the sample...
Terahertz pulsed imaging (TPI) is a powerful tool for nondestructive and quantitative characterization of pharmaceutical tablet coatings. In this paper, we present various processing methods for determining coating thickness from the measured terahertz waveform. We demonstrate that a wavelet-based method can be used to characterize the tablet coating with a thickness down to 25 microns, which is better...
Terahertz pulsed imaging (TPI) and optical coherence tomography (OCT) are two powerful techniques allowing high quality three-dimensional images from within scattering media to be obtained noninvasively. In this paper, we report experimental results of using TPI and OCT for characterizing layered samples including pharmaceutical coatings. We found that infrared OCT provides better axial resolutions...
We present the results of terahertz pulsed imaging (TPI) experiments to measure the `hardness' of pharmaceutical solid dosage forms (tablets) compacted at various compression forces. Results of TPI measurements are compared to those from diametric compression tests as well as finite element analysis (FEA) simulations of density distributions on the surface of the tablet. In both cases strong correlation...
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