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Purpose The challenge in developing liposomes to be used in active drug targeting is to design a method that can be used for modifying liposomal membranes that is applicable for a number of different specific ligands. In this study, the post insertion technique was used with activated sterol-PEG1300 anchors and was evaluated with regard to its effectiveness in active targeting in vitro. The key advantage...
A simple and inexpensive method for functionalization of preformed liposomes is presented. Soy sterol–PEG 1300 ethers are activated by tresylation at the end of the PEG chain. Coupling of bovine serum albumin as an amino group containing model ligand to the activated lipids can be performed at pH 8.4 with high efficiency. At room temperature, the mixture of sterol–PEG and sterol–PEG–protein...
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