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Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disorder characterized primarily by selective neurodegeneration of the motor neurons. The basis of diagnosis is the presence of signs of both upper and lower motor neuron involvement in more than one body region. ALS was considered until a few years ago a disease of young adults but recently population-based studies have consistently shown...
In the majority of cases, mitochondrial disorders are multisystem conditions that most frequently affect the skeletal muscle, followed by the central nervous system. One of the clinical manifestations of central nervous system involvement is Parkinson's syndrome (PS). Evidence for an association of mitochondrial defects with PS comes from mitochondrial disorder patients who have developed Parkinson's...
Alzheimer's disease usually causes dementia in the old people and the symptom progression of the disease phenotype displays certain patterns. One possible reason is that the nerve cells in the brains of the patients degenerate at different stages. Here, we analyze the dynamics of disease progression based on its biomolecular network. We develop a novel computational method to integrate an ensemble...
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