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We use empirical data to demonstrate a recently proposed framework for including measured genotypes in structural equation models (Van den Oord and Snieder, 2002). The sample consisted of 227 MZ pairs, 197 DZ pairs, and 41 DZ twins without co-twin. The mean age of the female twins was 57 years. The analysis aimed at studying the effect of the vitamin D receptor (VDR) gene polymorphism (VDRGP) on bone...
The etiology of complex traits may perhaps best be conceptualized by an interplay of multiple factors that mediate the influence of the genes on the eventual outcome. The possibilities of studying aspects of this interplay using existing methods are generally limited. We therefore propose a model with observed and latent variables that does not impose restrictions on the number of variables or the...
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