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We identified and characterized the membrane currents underlying spontaneous transient depolarization in the urethra. Myocytes were isolated from sheep urethra by enzymatic digestion and studied by the amphotericin B patch clamp method. Just more than 10% of cells had spontaneous transient inward currents when maintained at −60 mV. Mean amplitude plus or minus standard error of mean of the spontaneous...
Normal bladder development is believed to depend on the active work of the bladder for storing and expelling urine. When high urinary diversion is performed in infants and the bladder no longer undergoes normal filling, bladder development may be altered, ultimately resulting in bladder dysfunction. To help better understand this relationship of bladder function with growth at the cellular level we...
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