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The α1β1 integrin, very late antigen (VLA)-1, characterizes collagen adherent interferon (IFN) γ producing memory T cells in inflamed synovium. We now report that the mean percentage of VLA-1+ T cells is significantly lower among peripheral blood mononuclear cells of rheumatoid patients responsive to antitumor necrosis factor (TNF) α therapy than of those with active disease not receiving therapy...
The α1β1 integrin, also known as “very late antigen” (VLA)-1, is normally expressed on mesenchymal cells, some epithelial cells, activated T cells, and macrophages, and interacts, via the I-domain of the extracellular domain of the α1 subunit, with collagen molecules in the extracellular matrix (ECM). By “outside–in” transmembranal signaling to the interior of the cell, it mediates adhesion, migration,...
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