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This paper deals with the interpretation of the macroscopic features of epileptic spikes recorded in human hippocampus based on a neural network model of the CA1 subfield. The network consists of principal cells (pyramidal neurons) and local interneurons and uses GABAergic and glutamatergic synapses. For pyramidal cells, this paper introduces a novel two-compartment model that was developed using...
Using intracellular recording with a microelectrode, the authors studied the changes of heart-cell action potentials after administration of fluoride. The same results were obtained in various kinds of heart cells, including atrial, ventricular, sino-atrial node, Purkinje fiber, cultured myocardial, and ventricular cells in situ. Simulation analysis based on these results suggests that fluoride can...
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