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There is an urgent need to develop technology for continuous in vivo glucose monitoring in subjects with diabetes mellitus. Problems with existing devices based on electrochemistry have encouraged alternative approaches to glucose sensing in recent years, and those based on fluorescence intensity and lifetime have special advantages, including sensitivity and the potential for non-invasive measurement...
This paper demonstrates a novel fluorescence resonance energy transfer (RET) sensor system, wherein a competitive binding (CB) assay is encapsulated into microcapsules. For CB approaches intended as smart tattoos, microcapsules are superior to hydrogel microparticle systems, as they provide space in the capsule interior for the free movement of the sensing elements while maintaining constant sensing...
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