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Non-Invasive Glucose Monitoring devices use Multivariate Calibration (MC) methods to estimate glucose concentration in blood. The accuracy of methods depends on spectral data obtained from tongue-to-spectrometer interface. In this work we examine four widely used MC methods, they are: classical least square (CLS), inverse least square (ILS), principal component (PC) and partial least square (PLS)...
A novel minimally invasive way to measure blood glucose concentration is proposed by combining interstitial fluid (ISF) transdermal extraction and surface plasmon resonance (SPR) detection. 55 kHz low-frequency ultrasound pulses are applied for 30 seconds to enhance the skin permeability and then interstitial fluid is extracted out of skin by vacuum. The glucose concentration in the interstitial fluid...
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